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HIGHER EFFICACY

SODIUM SUCCINATE

Affects the main factors of OA progression:

  Hypoxia 

  Energy Deficiency

  Acidosis

  Free-radical Lipid Peroxidation

 Structural & Functional Impairments Of The Cartilage Matrix 

KREBS CYCLE / CITRIC ACID CYCLE (PART)

SUCCINATE  is an intermediate in the Krebs Cycle, and energy-yielding process

CARTILAGE MODIFYING EFFECTS OF DIART

45 days (Pre-Clinial Study)

"With DIART, complete filling of the bony-cartilaginous defect by the regenerate in 80% cases"

Monopreparation of HA

DIART Preparation

90 days post-injury

Monopreparation of HA

Partial filling of the bony-cartilaginous defect by the regenerate in administration of mono-preparation of hyaluronic acid. Loss of luster and appearance of roughness of the articular cartilage

DIART Preparation

Complete filling of the bony-cartilaginous defect by the regenerate in intra-articular administration of hyaluronic acid with sodium succinate. (DIART preparation)

Pain Relief & Activity Score

DEVELOPMENT OF DEGENERATIVE CHANGES
(KL OA GRADE 0 -III; 0 = Normal, III = Severe OA )
IN TRAUMATIC INJURIES

3 - 12 Months

3-12months

Results were maintained at 12 months without any Grade III

DIART Group n=44

(DIART weekly injections after absence of
all inflammation symptoms and exudate
(average 5-6 weeks)

6 Months

6months

12 Months

12months

Significant progression of OA in Comparison group

Comparison Group n=42

DIART Group n=44

(DIART weekly injections after absence of all inflammation symptoms and exudate
(average 5-6 weeks)

Comparison Group n=42

HOW DIART HELPS

DIART insertion directly to the seat of the pathological process helps to normalize key pathological factors* in traumatic knee injuries and also slows down the progression of OA while restoring the antioxidant defense in the affected joint.

  Proven to slow down OA progression

 Viscoinduction (stabilised)

DIART is a unique patented formulation that combines of Hyaluronic acid and Sodium Succinate for intra-articular administration, which have Antioxidants, Stabilizing, Chondrocytes-Stimulating and Chondroprotective properties affecting key pathogenetic mechanism in osteoarthritis development that is often left without treatment.

DIART is a unique patented formulation that combines of Hyaluronic acid and Sodium Succinate for intra-articular administration, which have Antioxidants, Stabilizing, Chondrocytes-Stimulating and Chondroprotective properties affecting key pathogenetic mechanism in osteoarthritis development that is often left without treatment.